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Timing is clinically important: GH is predominantly secreted during slow-wave sleep, and dosing 30 to 60 minutes before sleep allows Ipamorelin to work in synchrony with the natural nocturnal GH secretion cycle

After six months, TOTUM-63 reduced body weight, waist circumference, fasting blood glucose, and blood pressure in 51 participants with prediabetes or early stage type-2 diabetes (23)

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